Irritability in autistic children treated with fenfluramine.

Efficacy and Safety of Aripiprazole for Treatment of Irritability in Children with Autistic Disorder: An Open-Label Study

Genetics of childhood disorders: XLIV. autism, part 3: psychopharmacology of autism.

pervasive developmental disorders (PDDs) currently involves the treatment of target symptoms including hyperactivity, inattention, interfering repetitive thoughts and behavior, and aggression toward self, others, or the environment. Although studies in laboratory animals have identified neuropeptides, including oxytocin and vasopressin, that mediate some elements of affiliative behavior, drugs ...

Efficacy and Tolerability of Pharmacotherapy Options for the Treatment of Irritability in Autistic Children

Children with autism have a high rate of irritability and aggressive symptoms. Irritability or self-injurious behavior can result in significant harm to those affected, as well as to marked distress for their families. This paper provides a literature review regarding the efficacy and tolerability of pharmacotherapy for the treatment of irritability in autistic children. Although antipsychotics...

Aripiprazole in the treatment of irritability in children and adolescents with autistic disorder.

OBJECTIVE The objective of this study was to evaluate short-term efficacy and safety of aripiprazole in the treatment of irritability in children and adolescents with autistic disorder who were manifesting behaviors such as tantrums, aggression, self-injurious behavior, or a combination of these. METHODS This 8-week, double-blind, randomized, placebo-controlled, parallel-group study was condu...

Event-related potentials and monoamines in autistic children on a clinical trial of fenfluramine.

In a double blind, crossover study of the response of autistic subjects to fenfluramine, event-related potentials (ERPs) were recorded from 7 subjects on an attention-demanding auditory choice reaction time task (ACRT). ACRT, IQ and biochemical measures were taken after 5 months placebo and 5 months fenfluramine treatment. After fenfluramine treatment blood serotonin levels fell, urinary catech...